Non-steroidal anti-inflammatory drug induced injury to the small intestine.
Identifieur interne : 001848 ( Main/Exploration ); précédent : 001847; suivant : 001849Non-steroidal anti-inflammatory drug induced injury to the small intestine.
Auteurs : RBID : pubmed:20608226English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Anti-Inflammatory Agents, Non-Steroidal, Aspirin.
- chemically induced : Intestinal Diseases.
- diagnosis : Intestinal Diseases.
- drug effects : Intestine, Small.
- pathology : Intestinal Diseases, Intestine, Small.
- Diagnosis, Differential, Humans.
Abstract
Non-steroidal anti-inflammatory drug (NSAIDs) induced enteropathy represents an important complication of one of the most commonly used drugs worldwide. Due to previous diagnostics difficulties the real prevalence of this disease was underestimated for a long time. The pathogenesis of NSAID-enteropathy is more multifactorial and complex than formerly assumed but has still not been fully uncovered. A combination of the local and systemic effect plays an important role in pathogenesis. Thanks to novel enteroscopy methods (wireless capsule endoscopy, double balloon enteroscopy), small bowel lesions are described in a substantial section of NSAID users although most are clinically asymptomatic. The other non-invasive tests (small bowel permeability, faecal calprotectin, scintigraphy using faecal excretion of 111-indium-labelled leukocytes etc.) proposed for diagnostics are not generally used in clinical practice, mainly because of their non-specificity. Despite intensive research into possible treatment, the main measure for patients with NSAID-enteropathy is still withdrawal of NSAIDs. Double balloon enteroscopy plays an important role in the treatment of complications (bleeding, strictures).
PubMed: 20608226
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-steroidal anti-inflammatory drug induced injury to the small intestine.</title><author><name sortKey="Tachec, Ilja" uniqKey="Tachec I">Ilja Tachecí</name><affiliation wicri:level="1"><nlm:affiliation>Charles University in Praha, Faculty of Medicine and 2nd Department of Internal Medicine, Division of Gastroenterology, University Hospital Hradec Králové, Czech Republic. tacheci@gmail.com</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University in Praha, Faculty of Medicine and 2nd Department of Internal Medicine, Division of Gastroenterology, University Hospital Hradec Králové</wicri:regionArea></affiliation></author><author><name sortKey="Kop Cov, Marcela" uniqKey="Kop Cov M">Marcela Kopácová</name></author><author><name sortKey="Rejchrt, Stanislav" uniqKey="Rejchrt S">Stanislav Rejchrt</name></author><author><name sortKey="Bures, Jan" uniqKey="Bures J">Jan Bures</name></author></titleStmt><publicationStmt><date when="2010">2010</date><idno type="RBID">pubmed:20608226</idno><idno type="pmid">20608226</idno><idno type="wicri:Area/Main/Corpus">001858</idno><idno type="wicri:Area/Main/Curation">001858</idno><idno type="wicri:Area/Main/Exploration">001848</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal (adverse effects)</term><term>Aspirin (adverse effects)</term><term>Diagnosis, Differential</term><term>Humans</term><term>Intestinal Diseases (chemically induced)</term><term>Intestinal Diseases (diagnosis)</term><term>Intestinal Diseases (pathology)</term><term>Intestine, Small (drug effects)</term><term>Intestine, Small (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Aspirin</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Intestinal Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Intestinal Diseases</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Intestine, Small</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Intestinal Diseases</term><term>Intestine, Small</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-steroidal anti-inflammatory drug (NSAIDs) induced enteropathy represents an important complication of one of the most commonly used drugs worldwide. Due to previous diagnostics difficulties the real prevalence of this disease was underestimated for a long time. The pathogenesis of NSAID-enteropathy is more multifactorial and complex than formerly assumed but has still not been fully uncovered. A combination of the local and systemic effect plays an important role in pathogenesis. Thanks to novel enteroscopy methods (wireless capsule endoscopy, double balloon enteroscopy), small bowel lesions are described in a substantial section of NSAID users although most are clinically asymptomatic. The other non-invasive tests (small bowel permeability, faecal calprotectin, scintigraphy using faecal excretion of 111-indium-labelled leukocytes etc.) proposed for diagnostics are not generally used in clinical practice, mainly because of their non-specificity. Despite intensive research into possible treatment, the main measure for patients with NSAID-enteropathy is still withdrawal of NSAIDs. Double balloon enteroscopy plays an important role in the treatment of complications (bleeding, strictures).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20608226</PMID><DateCreated><Year>2010</Year><Month>07</Month><Day>07</Day></DateCreated><DateCompleted><Year>2010</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1211-4286</ISSN><JournalIssue CitedMedium="Print"><Volume>53</Volume><Issue>1</Issue><PubDate><Year>2010</Year></PubDate></JournalIssue><Title>Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové</Title><ISOAbbreviation>Acta Medica (Hradec Kralove)</ISOAbbreviation></Journal><ArticleTitle>Non-steroidal anti-inflammatory drug induced injury to the small intestine.</ArticleTitle><Pagination><MedlinePgn>3-11</MedlinePgn></Pagination><Abstract><AbstractText>Non-steroidal anti-inflammatory drug (NSAIDs) induced enteropathy represents an important complication of one of the most commonly used drugs worldwide. Due to previous diagnostics difficulties the real prevalence of this disease was underestimated for a long time. The pathogenesis of NSAID-enteropathy is more multifactorial and complex than formerly assumed but has still not been fully uncovered. A combination of the local and systemic effect plays an important role in pathogenesis. Thanks to novel enteroscopy methods (wireless capsule endoscopy, double balloon enteroscopy), small bowel lesions are described in a substantial section of NSAID users although most are clinically asymptomatic. The other non-invasive tests (small bowel permeability, faecal calprotectin, scintigraphy using faecal excretion of 111-indium-labelled leukocytes etc.) proposed for diagnostics are not generally used in clinical practice, mainly because of their non-specificity. Despite intensive research into possible treatment, the main measure for patients with NSAID-enteropathy is still withdrawal of NSAIDs. Double balloon enteroscopy plays an important role in the treatment of complications (bleeding, strictures).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tachecí</LastName><ForeName>Ilja</ForeName><Initials>I</Initials><Affiliation>Charles University in Praha, Faculty of Medicine and 2nd Department of Internal Medicine, Division of Gastroenterology, University Hospital Hradec Králové, Czech Republic. tacheci@gmail.com</Affiliation></Author><Author ValidYN="Y"><LastName>Kopácová</LastName><ForeName>Marcela</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rejchrt</LastName><ForeName>Stanislav</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Bures</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType><PublicationType>Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Czech Republic</Country><MedlineTA>Acta Medica (Hradec Kralove)</MedlineTA><NlmUniqueID>9705947</NlmUniqueID><ISSNLinking>1211-4286</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Anti-Inflammatory Agents, Non-Steroidal</NameOfSubstance></Chemical><Chemical><RegistryNumber>R16CO5Y76E</RegistryNumber><NameOfSubstance>Aspirin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Anti-Inflammatory Agents, Non-Steroidal</DescriptorName><QualifierName MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aspirin</DescriptorName><QualifierName MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Intestinal Diseases</DescriptorName><QualifierName MajorTopicYN="Y">chemically induced</QualifierName><QualifierName MajorTopicYN="N">diagnosis</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Intestine, Small</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>94</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20608226</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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